From fruit flies to better sleep: Yiwen Su ’26 explores the neural rhythms of rest

Yiwen Su ’26 is working to unlock the secrets of a good night’s sleep — starting with the circadian rhythms of fruit flies.
The neuroscience major from Beijing, China, has been working with Professor of Neuroscience Chris Vecsey to study how sleep is regulated in fruit flies by tracking specific neurons and their interactions.
It’s the third year Yiwen has participated in ’s Faculty-Student Summer Research (FSSR) program. In 2025, more than 120 students participated in projects in fields as disparate as computer science and anthropology.
Yiwen’s research with Vecsey seeks to understand how a neurotransmitter called octopamine — the invertebrate equivalent of norepinephrine — affects sleep through its influence on specific neural pathways.
“My current research focuses on how octopamine neurons interact with astrocytes, insulin-producing cells, and specific clock neurons in the drosophila brain,” Yiwen explained.
“I want to understand how activating or silencing these pathways alters sleep behavior. It's like adding new players to the game to map out the full picture.”
By investigating the molecular and circuit-level mechanisms that control being asleep or awake, their research aims to shed light on the processes that keep internal clocks running smoothly and could eventually offer broader insight into sleep disturbances, including for humans.
From lab assistant to independent researcher
Professor Vecsey, who specializes in the neurobiology of sleep, says students’ involvement is central to his lab’s success.
undergraduates do 95% of the experimentation that happens in my lab."Chris VecseyProfessor of Neuroscience
“My role is primarily to teach students how to think about their project, how to do the techniques, and how to analyze and write up their results," Vecsey said. "But then the ball is in their court to actually do all of that themselves.”
He emphasizes the importance of creative thinking and encourages students like Yiwen to propose their own research ideas.
“When students first join my lab, their final assignment for the semester is to propose a project they’d like to carry out,” he said. “Yiwen has really embraced that opportunity. She’s taken ownership of her ideas and run with them.”
Yiwen’s research journey began in her first year at when a friend introduced her to the FSSR program. She contacted Professor of Biology Bernard Possidente and spent her first summer exploring fruit fly and mouse models related to circadian rhythms.
That experience laid the groundwork for Yiwen to join Vecsey’s lab the following year, where she could focus more deeply on fruit fly models of sleep regulation. She’s continued every semester — and every summer — since.
“Don’t hesitate to reach out to professors,” Yiwen advises. “Take the first step — opportunities often go to those who are brave enough to ask.”
Last summer, with the support of a Summer Experience Fund stipend from , Yiwen interned with a lab at SUNY Albany, where she trained on two-photon microscopy — a cutting-edge imaging technique.

Yiwen Su ’26 uses a microscope to study the sleep of fruit flies in a lab in 's Billie Tisch Center for Integrated Sciences.
A year later, is launching a new project requiring two-photon capabilities.Vecsey said Yiwen is a natural fit for the new research project, which will use a fluorescent sensor to detect where a sleep-promoting protein called sNPF is used as a signal in the brain.
Building a future in science
Yiwen once questioned whether a research career was for her, but her experiences at have reshaped her confidence — and her plans for the future.
“I see that good research comes from time, patience, and persistence,” she said. “Through this experience, I’ve become confident I want to pursue graduate school and contribute to research in a meaningful way.”
Vecsey says that Yiwen’s growth as a researcher has been remarkable.
“Yiwen’s creativity and determination are exactly what makes our research thrive. She’s curious, resourceful, and never afraid to try something new,” he said. “That’s what science needs.”
Yiwen says ’s small classes, strong mentorship, and unique opportunities available in Saratoga Springs have allowed her to grow in and out of the lab.
“Faculty and students here are both really chill, but also really focused. You can always get inspired and valuable suggestions from your peers and professors,” said Yiwen, who also serves as a teaching assistant in biology and organic chemistry courses. “Being in Saratoga Springs has been a wonderful part of my experience — it’s a safe, beautiful, and peaceful place that allows me to focus on academics and research.”
“At the same time, it's located just a few hours from major cities like New York and Boston. When I need a break, there are beautiful lakes nearby, like Saratoga Lake and Lake George, which are perfect for swimming, kayaking, or just relaxing by the water.
Vecsey says his work with students like Yiwen also motivates him.
“It’s incredibly rewarding to hear a research student gush about their new data, or to see their excitement when they finally succeed with a challenging technique,” he said. “That enthusiasm is contagious — and keeps my lab moving in exciting directions.”